Review



ingenuity pathway analysis ipa software suite  (Ingenuity Systems)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 86
      Buy from Supplier

    Structured Review

    Ingenuity Systems ingenuity pathway analysis ipa software suite
    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the <t>IPA</t> database. <t>IPA,</t> <t>Ingenuity</t> Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Ingenuity Pathway Analysis Ipa Software Suite, supplied by Ingenuity Systems, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/analysis+ipa+pathway/pmc13131438-159-1-7
    Average 86 stars, based on 1 article reviews
    ingenuity pathway analysis ipa software suite - by Bioz Stars, 2026-11
    86/100 stars

    Images

    1) Product Images from "Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft"

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft

    Journal: Journal of Advanced Research

    doi: 10.1016/j.jare.2025.07.059

    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Figure Legend Snippet: GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Techniques Used: Protein-Protein interactions, Expressing, Activity Assay

    GSEA of GO biological process gene sets in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched GO biological process gene sets were nitric oxide mediated transduction (a), central nervous system neuron axongenesis (c), positive regulation of epithelial mesenchymal transition (e), regulation of JNK cascade (j), regulation of cellular response to insulin stimulus (i), and maintenance of blood brain barrier (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO biological process gene sets (b, d, f, h, j, l). The enrichment heat-map showing the dynamic activity of diseases and functions at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each disease and function are depicted with a pseudo color (orange for an activated disease and function with positive Z-score ≥2, blue for an inhibited disease and function with negative Z-score ≤−2, and spot for a non-active disease and function with −2 ≤ Z-score ≤2). The diseases and functions were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Figure Legend Snippet: GSEA of GO biological process gene sets in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched GO biological process gene sets were nitric oxide mediated transduction (a), central nervous system neuron axongenesis (c), positive regulation of epithelial mesenchymal transition (e), regulation of JNK cascade (j), regulation of cellular response to insulin stimulus (i), and maintenance of blood brain barrier (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO biological process gene sets (b, d, f, h, j, l). The enrichment heat-map showing the dynamic activity of diseases and functions at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each disease and function are depicted with a pseudo color (orange for an activated disease and function with positive Z-score ≥2, blue for an inhibited disease and function with negative Z-score ≤−2, and spot for a non-active disease and function with −2 ≤ Z-score ≤2). The diseases and functions were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Techniques Used: Transduction, Expressing, Activity Assay

    GSEA of GO cellular component, molecular function, and upstream regulators prediction in the DRG tissues post-surgery. Ranked by NES score, the selected three of top 20 enriched GO cellular component gene sets were cytoplasmic stress granule (a), P body (c), actin-based cell projection (e), the selected three of top 20 enriched GO molecular function gene sets were ATPase binding (g), kinase inhibitor activity (i), and Smad binding (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO cellular component (b, d, f) and molecular function (h, j, l) gene sets. The enrichment heatmap showing the predicted upstream regulators at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each predicted upstream regulator is depicted with a pseudo color (orange for an activated upstream regulator with positive Z-score ≥2, blue for an inhibited upstream regulator with negative Z-score ≤−2, and spot for a non-active upstream regulator with −2 ≤ Z-score ≤2). The predicted upstream regulators were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Figure Legend Snippet: GSEA of GO cellular component, molecular function, and upstream regulators prediction in the DRG tissues post-surgery. Ranked by NES score, the selected three of top 20 enriched GO cellular component gene sets were cytoplasmic stress granule (a), P body (c), actin-based cell projection (e), the selected three of top 20 enriched GO molecular function gene sets were ATPase binding (g), kinase inhibitor activity (i), and Smad binding (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO cellular component (b, d, f) and molecular function (h, j, l) gene sets. The enrichment heatmap showing the predicted upstream regulators at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each predicted upstream regulator is depicted with a pseudo color (orange for an activated upstream regulator with positive Z-score ≥2, blue for an inhibited upstream regulator with negative Z-score ≤−2, and spot for a non-active upstream regulator with −2 ≤ Z-score ≤2). The predicted upstream regulators were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Techniques Used: Binding Assay, Activity Assay, Expressing

    The impact of DRG neuron axonal promotion via SKP-SCs. (a) Schematic illustration of DRG neurons culture in vitro. The cultured DRG neurons for 20 h and 40 h (b) showed increased neurite outgrowth. Scale bar: 50 μm. (c) The β-Tubulin III cell immunofluorescent staining (red) showed neurites are undergoing a process of growth in length from 48 h to 96 h. Scale bar: 50 μm. Schematic illustration showed the direct (d) and in-direct (Transwell®) (e) co-culture of DRG neurons and SKP-SCs. (h) After direct co-culture 48 h, GFP-SKP-SCs promoted DRGs neurite outgrowth significantly compared to control group (i). (k) After in-direct co-culture 72 h, GFP-SKP-SCs promoted DRGs neurite outgrowth (j) significantly compared to control group (g). Scale bar: 50 μm for f, g, i, j. (l) Morphological changes under phase contrast microscopy in DRG neurons and SKP-SCs direct co-culture, DRG neurons in separate culture, and in-direct (Transwell®) co-culture of DRG neurons and SKP-SCs after 24 h, 48 h, and 72 h. Scale bar: 100 μm. (m) Schematic illustration of LC-MS/MS analysis to identify the secreted proteins from SKP-SCs cultured in serum free basic medium for 4 h. After concentration, the cleared conditioned medium was collected for LC-MS/MS analysis, database search, and protein identification. The enrichment analysis showed top 20 diseases and functions (n) and canonical pathways (o) according to the IPA database. The PPI network shows the interaction of the proteins involved in the functions highly correlated with regeneration (p). Among them, functions as formation of lamellipodia, extension of neurites, extension of cellular protrusions, and related proteins were highlighted (q). Functions as migration of endothelial cells, development of endothelial tissue, vasculogenesis, development of epithelial tissue, endothelial cell development, and related proteins were highlighted (r). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Figure Legend Snippet: The impact of DRG neuron axonal promotion via SKP-SCs. (a) Schematic illustration of DRG neurons culture in vitro. The cultured DRG neurons for 20 h and 40 h (b) showed increased neurite outgrowth. Scale bar: 50 μm. (c) The β-Tubulin III cell immunofluorescent staining (red) showed neurites are undergoing a process of growth in length from 48 h to 96 h. Scale bar: 50 μm. Schematic illustration showed the direct (d) and in-direct (Transwell®) (e) co-culture of DRG neurons and SKP-SCs. (h) After direct co-culture 48 h, GFP-SKP-SCs promoted DRGs neurite outgrowth significantly compared to control group (i). (k) After in-direct co-culture 72 h, GFP-SKP-SCs promoted DRGs neurite outgrowth (j) significantly compared to control group (g). Scale bar: 50 μm for f, g, i, j. (l) Morphological changes under phase contrast microscopy in DRG neurons and SKP-SCs direct co-culture, DRG neurons in separate culture, and in-direct (Transwell®) co-culture of DRG neurons and SKP-SCs after 24 h, 48 h, and 72 h. Scale bar: 100 μm. (m) Schematic illustration of LC-MS/MS analysis to identify the secreted proteins from SKP-SCs cultured in serum free basic medium for 4 h. After concentration, the cleared conditioned medium was collected for LC-MS/MS analysis, database search, and protein identification. The enrichment analysis showed top 20 diseases and functions (n) and canonical pathways (o) according to the IPA database. The PPI network shows the interaction of the proteins involved in the functions highly correlated with regeneration (p). Among them, functions as formation of lamellipodia, extension of neurites, extension of cellular protrusions, and related proteins were highlighted (q). Functions as migration of endothelial cells, development of endothelial tissue, vasculogenesis, development of epithelial tissue, endothelial cell development, and related proteins were highlighted (r). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Techniques Used: In Vitro, Cell Culture, Staining, Co-Culture Assay, Control, Microscopy, Liquid Chromatography with Mass Spectroscopy, Concentration Assay, Migration, Activation Assay, Inhibition

    The transcriptional alteration of DRG neurons co-cultured with SKP-SCs. (a) Representative images of phase contrast microscopy of SKP-SCs in the upper chamber and lower ventricular DRG neurons after 48 h co-culture. Scale bar: 100 μm. (b) Schematic illustration of transcriptional analysis of lower ventricular DRG neurons for 48 h co-culture, and bioinformatics. The enrichment analysis showed top 20 diseases and functions (c) and canonical pathways (d) according to the IPA database. The PPI network shows the interaction of the key proteins involved in the functions highly correlated with regeneration (e). Up-regulated EGR2 (red) was selected to show multi-functions highly correlated with neuroregeneration (f). The interaction network of downstream regulators of EGR2, its downstream up-regulated (red) genes and down-regulated (green) proteins and their functions (g). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. Color intensity of the nodes in networks were proportional to differentially expression level. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Figure Legend Snippet: The transcriptional alteration of DRG neurons co-cultured with SKP-SCs. (a) Representative images of phase contrast microscopy of SKP-SCs in the upper chamber and lower ventricular DRG neurons after 48 h co-culture. Scale bar: 100 μm. (b) Schematic illustration of transcriptional analysis of lower ventricular DRG neurons for 48 h co-culture, and bioinformatics. The enrichment analysis showed top 20 diseases and functions (c) and canonical pathways (d) according to the IPA database. The PPI network shows the interaction of the key proteins involved in the functions highly correlated with regeneration (e). Up-regulated EGR2 (red) was selected to show multi-functions highly correlated with neuroregeneration (f). The interaction network of downstream regulators of EGR2, its downstream up-regulated (red) genes and down-regulated (green) proteins and their functions (g). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. Color intensity of the nodes in networks were proportional to differentially expression level. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Techniques Used: Cell Culture, Microscopy, Co-Culture Assay, Activation Assay, Inhibition, Expressing

    Related Articles

    Software:

    Article Title: Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice.
    Article Snippet: Accepted Manuscript Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice Annette Bernhard, Marc H.G.. Berntssen, Anne-Katrine Lundebye, Anita R. Alvheim, Lene Secher Myrmel, Even Fjære, Bente E. Torstensen, Karsten Kristiansen, Lise Madsen, Trond Brattelid, Josef D. Rasinger PII: S0278-6915(16)30352-0 DOI: 10.1016/j.fct.2016.10.002 Reference: FCT 8743 To appear in: Food and Chemical Toxicology Received Date: 27 May 2016 Revised Date: 29 September 2016 Accepted Date: 2 October 2016 Please cite this article as: Bernhard, A., Berntssen, M.H.G., Lundebye, A.-K., Alvheim, A.R., Myrmel, L.S., Fjære, E., Torstensen, B.E., Kristiansen, K., Madsen, L., Brattelid, T., Rasinger, J.D., Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice, Food and Chemical Toxicology (2016), doi: 10.1016/j.fct.2016.10.002.. This is a PDF file of an unedited manuscript that has been accepted for publication.

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft
    Article Snippet: .. The Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA) was employed to identify canonical pathways that are significantly overrepresented. ..

    Article Title: Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish ( Danio rerio ) progeny
    Article Snippet: .. Concordant gene symbols of DEGs (adjusted p-value<0.05) of F 1 generation were sent to Ingenuity ® Pathway Analysis software suite (IPA ® , Ingenuity Systems, Qiagen, Redwood City, USA) for downstream analysis. ..

    Article Title: Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny.
    Article Snippet: .. Concordant gene symbols of DEGs (adjusted p-value<0.05) of F1 generation were sent to Ingenuity1 Pathway Analysis software suite (IPA1, Ingenuity Systems, Qiagen, Redwood City, USA) for downstream analysis. ..

    Article Title: Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice.
    Article Snippet: .. Uniprot-Swissprot Accession numbers of identified differentially expressed (p<0.05) proteins were uploaded into the Ingenuity Pathway Analysis software suite (IPA, Ingenuity Systems, USA). ..

    Article Title: Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid.
    Article Snippet: .. DEG were converted to human orthologues to identify upstream regulators that can explain the observed gene expression changes using Ingenuity Pathway Analysis software suite (IPA, Ingenuity Systems, USA). ..

    Article Title: Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity
    Article Snippet: .. Genes passing these thresholds were imported into the Ingenuity Pathway Analysis software suite and mapped onto their corresponding objects in the Ingenuity Knowledge Base (IPA, Ingenuity Systems, USA). ..

    Indirect Immunoperoxidase Assay:

    Article Title: Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice.
    Article Snippet: Accepted Manuscript Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice Annette Bernhard, Marc H.G.. Berntssen, Anne-Katrine Lundebye, Anita R. Alvheim, Lene Secher Myrmel, Even Fjære, Bente E. Torstensen, Karsten Kristiansen, Lise Madsen, Trond Brattelid, Josef D. Rasinger PII: S0278-6915(16)30352-0 DOI: 10.1016/j.fct.2016.10.002 Reference: FCT 8743 To appear in: Food and Chemical Toxicology Received Date: 27 May 2016 Revised Date: 29 September 2016 Accepted Date: 2 October 2016 Please cite this article as: Bernhard, A., Berntssen, M.H.G., Lundebye, A.-K., Alvheim, A.R., Myrmel, L.S., Fjære, E., Torstensen, B.E., Kristiansen, K., Madsen, L., Brattelid, T., Rasinger, J.D., Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice, Food and Chemical Toxicology (2016), doi: 10.1016/j.fct.2016.10.002.. This is a PDF file of an unedited manuscript that has been accepted for publication.

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft
    Article Snippet: .. The Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA) was employed to identify canonical pathways that are significantly overrepresented. ..

    Article Title: Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish ( Danio rerio ) progeny
    Article Snippet: .. Concordant gene symbols of DEGs (adjusted p-value<0.05) of F 1 generation were sent to Ingenuity ® Pathway Analysis software suite (IPA ® , Ingenuity Systems, Qiagen, Redwood City, USA) for downstream analysis. ..

    Article Title: Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice.
    Article Snippet: .. Uniprot-Swissprot Accession numbers of identified differentially expressed (p<0.05) proteins were uploaded into the Ingenuity Pathway Analysis software suite (IPA, Ingenuity Systems, USA). ..

    Article Title: Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid.
    Article Snippet: .. DEG were converted to human orthologues to identify upstream regulators that can explain the observed gene expression changes using Ingenuity Pathway Analysis software suite (IPA, Ingenuity Systems, USA). ..

    Article Title: Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity
    Article Snippet: .. Genes passing these thresholds were imported into the Ingenuity Pathway Analysis software suite and mapped onto their corresponding objects in the Ingenuity Knowledge Base (IPA, Ingenuity Systems, USA). ..

    other:

    Article Title: Hepatocyte Nuclear Factors 4 α and 1 α Regulate Kidney Developmental Expression of Drug-Metabolizing Enzymes and Drug Transporters
    Article Snippet: For network analysis, probe IDs were imported into the Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA).

    Gene Expression:

    Article Title: Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid.
    Article Snippet: .. DEG were converted to human orthologues to identify upstream regulators that can explain the observed gene expression changes using Ingenuity Pathway Analysis software suite (IPA, Ingenuity Systems, USA). ..



    Similar Products

    analysis software suite  (Aurora Scientific)
    86
    Aurora Scientific analysis software suite
    Analysis Software Suite, supplied by Aurora Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/615a+analysis+software+suite/pm42251040-307-5-8
    Average 86 stars, based on 1 article reviews
    analysis software suite - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    legendplextm data analysis software suite  (Qognit Inc)
    86
    Qognit Inc legendplextm data analysis software suite
    Legendplextm Data Analysis Software Suite, supplied by Qognit Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/analysis+based+cloud+data+legendplex+software/pm42156885-368-7-6
    Average 86 stars, based on 1 article reviews
    legendplextm data analysis software suite - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    mri analysis software suite v3 0  (Niumag Corporation)
    86
    Niumag Corporation mri analysis software suite v3 0
    Mri Analysis Software Suite V3 0, supplied by Niumag Corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/0+image+nmr+processing+software+v3/pm42155261-63-15-20
    Average 86 stars, based on 1 article reviews
    mri analysis software suite v3 0 - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    ingenuity pathway analysis ipa software suite  (Ingenuity Systems)
    86
    Ingenuity Systems ingenuity pathway analysis ipa software suite
    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the <t>IPA</t> database. <t>IPA,</t> <t>Ingenuity</t> Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Ingenuity Pathway Analysis Ipa Software Suite, supplied by Ingenuity Systems, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/analysis+ipa+pathway/pmc13131438-159-1-7
    Average 86 stars, based on 1 article reviews
    ingenuity pathway analysis ipa software suite - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    615a analysis software suite  (Aurora Scientific)
    86
    Aurora Scientific 615a analysis software suite
    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the <t>IPA</t> database. <t>IPA,</t> <t>Ingenuity</t> Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    615a Analysis Software Suite, supplied by Aurora Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/615a+analysis+software+suite/10__1134_slash_s002209302602016x-49-6-4
    Average 86 stars, based on 1 article reviews
    615a analysis software suite - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    xrd analysis  (Bruker Corporation)
    96
    Bruker Corporation xrd analysis
    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the <t>IPA</t> database. <t>IPA,</t> <t>Ingenuity</t> Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Xrd Analysis, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/XRD+Software+-+DIFFRAC%2ESUITE/pmc12890852-373-0-9
    Average 96 stars, based on 1 article reviews
    xrd analysis - by Bioz Stars, 2026-11
    96/100 stars
    		  Buy from Supplier
    genomic suite analysis version 7 software  (Partek)
    86
    Partek genomic suite analysis version 7 software
    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the <t>IPA</t> database. <t>IPA,</t> <t>Ingenuity</t> Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Genomic Suite Analysis Version 7 Software, supplied by Partek, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/flow+partek+software/pmc13004022-282-13-12
    Average 86 stars, based on 1 article reviews
    genomic suite analysis version 7 software - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    smrt link analysis software suite  (Pacific Biosciences)
    86
    Pacific Biosciences smrt link analysis software suite
    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the <t>IPA</t> database. <t>IPA,</t> <t>Ingenuity</t> Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
    Smrt Link Analysis Software Suite, supplied by Pacific Biosciences, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/analysis+suite+software/link+smrt+software/pmc13045334-150-21-26
    Average 86 stars, based on 1 article reviews
    smrt link analysis software suite - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Journal: Journal of Advanced Research

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft

    doi: 10.1016/j.jare.2025.07.059

    Figure Lengend Snippet: GSEA of KEGG pathways and canonical pathways analysis in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched KEGG pathways were the Adherens Junction (a), JAK-STAT (d), NOD like receptor (g), Apoptosis (j), WNT (m), and MAPK (p) signaling pathways. The heat maps showing the dynamic expression of the core enrichment genes involved in these signaling pathways (b, e, h, k, n, q). The PPI network shows the interaction of the proteins involved in the above signaling pathways (c, f, i, l, o, r). The enrichment heat-map showing the dynamic activity of canonical pathways at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (s). Each pathway is depicted with a pseudo color (orange for an activated pathway with positive Z-score ≥2, blue for an inhibited pathway with negative Z-score ≤−2, and spot for a non-active pathway with −2 ≤ Z-score ≤2). The canonical pathways were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Article Snippet: The Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA) was employed to identify canonical pathways that are significantly overrepresented.

    Techniques: Protein-Protein interactions, Expressing, Activity Assay

    GSEA of GO biological process gene sets in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched GO biological process gene sets were nitric oxide mediated transduction (a), central nervous system neuron axongenesis (c), positive regulation of epithelial mesenchymal transition (e), regulation of JNK cascade (j), regulation of cellular response to insulin stimulus (i), and maintenance of blood brain barrier (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO biological process gene sets (b, d, f, h, j, l). The enrichment heat-map showing the dynamic activity of diseases and functions at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each disease and function are depicted with a pseudo color (orange for an activated disease and function with positive Z-score ≥2, blue for an inhibited disease and function with negative Z-score ≤−2, and spot for a non-active disease and function with −2 ≤ Z-score ≤2). The diseases and functions were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Journal: Journal of Advanced Research

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft

    doi: 10.1016/j.jare.2025.07.059

    Figure Lengend Snippet: GSEA of GO biological process gene sets in the DRG tissues post-surgery. Ranked by NES score, the selected six of top 20 enriched GO biological process gene sets were nitric oxide mediated transduction (a), central nervous system neuron axongenesis (c), positive regulation of epithelial mesenchymal transition (e), regulation of JNK cascade (j), regulation of cellular response to insulin stimulus (i), and maintenance of blood brain barrier (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO biological process gene sets (b, d, f, h, j, l). The enrichment heat-map showing the dynamic activity of diseases and functions at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each disease and function are depicted with a pseudo color (orange for an activated disease and function with positive Z-score ≥2, blue for an inhibited disease and function with negative Z-score ≤−2, and spot for a non-active disease and function with −2 ≤ Z-score ≤2). The diseases and functions were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Article Snippet: The Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA) was employed to identify canonical pathways that are significantly overrepresented.

    Techniques: Transduction, Expressing, Activity Assay

    GSEA of GO cellular component, molecular function, and upstream regulators prediction in the DRG tissues post-surgery. Ranked by NES score, the selected three of top 20 enriched GO cellular component gene sets were cytoplasmic stress granule (a), P body (c), actin-based cell projection (e), the selected three of top 20 enriched GO molecular function gene sets were ATPase binding (g), kinase inhibitor activity (i), and Smad binding (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO cellular component (b, d, f) and molecular function (h, j, l) gene sets. The enrichment heatmap showing the predicted upstream regulators at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each predicted upstream regulator is depicted with a pseudo color (orange for an activated upstream regulator with positive Z-score ≥2, blue for an inhibited upstream regulator with negative Z-score ≤−2, and spot for a non-active upstream regulator with −2 ≤ Z-score ≤2). The predicted upstream regulators were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Journal: Journal of Advanced Research

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft

    doi: 10.1016/j.jare.2025.07.059

    Figure Lengend Snippet: GSEA of GO cellular component, molecular function, and upstream regulators prediction in the DRG tissues post-surgery. Ranked by NES score, the selected three of top 20 enriched GO cellular component gene sets were cytoplasmic stress granule (a), P body (c), actin-based cell projection (e), the selected three of top 20 enriched GO molecular function gene sets were ATPase binding (g), kinase inhibitor activity (i), and Smad binding (k). The heatmaps showing the dynamic expression of the core enrichment genes involved in these GO cellular component (b, d, f) and molecular function (h, j, l) gene sets. The enrichment heatmap showing the predicted upstream regulators at 6 h, 12 h, 1 d, 4 d, 7 d, and 14 d post-surgery (m). Each predicted upstream regulator is depicted with a pseudo color (orange for an activated upstream regulator with positive Z-score ≥2, blue for an inhibited upstream regulator with negative Z-score ≤−2, and spot for a non-active upstream regulator with −2 ≤ Z-score ≤2). The predicted upstream regulators were classified into different types according to the IPA database. IPA, Ingenuity Pathway Analysis. GSEA, gene set enrichment analysis; NES, normalized enrichment score; PPI, protein–protein interaction. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Article Snippet: The Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA) was employed to identify canonical pathways that are significantly overrepresented.

    Techniques: Binding Assay, Activity Assay, Expressing

    The impact of DRG neuron axonal promotion via SKP-SCs. (a) Schematic illustration of DRG neurons culture in vitro. The cultured DRG neurons for 20 h and 40 h (b) showed increased neurite outgrowth. Scale bar: 50 μm. (c) The β-Tubulin III cell immunofluorescent staining (red) showed neurites are undergoing a process of growth in length from 48 h to 96 h. Scale bar: 50 μm. Schematic illustration showed the direct (d) and in-direct (Transwell®) (e) co-culture of DRG neurons and SKP-SCs. (h) After direct co-culture 48 h, GFP-SKP-SCs promoted DRGs neurite outgrowth significantly compared to control group (i). (k) After in-direct co-culture 72 h, GFP-SKP-SCs promoted DRGs neurite outgrowth (j) significantly compared to control group (g). Scale bar: 50 μm for f, g, i, j. (l) Morphological changes under phase contrast microscopy in DRG neurons and SKP-SCs direct co-culture, DRG neurons in separate culture, and in-direct (Transwell®) co-culture of DRG neurons and SKP-SCs after 24 h, 48 h, and 72 h. Scale bar: 100 μm. (m) Schematic illustration of LC-MS/MS analysis to identify the secreted proteins from SKP-SCs cultured in serum free basic medium for 4 h. After concentration, the cleared conditioned medium was collected for LC-MS/MS analysis, database search, and protein identification. The enrichment analysis showed top 20 diseases and functions (n) and canonical pathways (o) according to the IPA database. The PPI network shows the interaction of the proteins involved in the functions highly correlated with regeneration (p). Among them, functions as formation of lamellipodia, extension of neurites, extension of cellular protrusions, and related proteins were highlighted (q). Functions as migration of endothelial cells, development of endothelial tissue, vasculogenesis, development of epithelial tissue, endothelial cell development, and related proteins were highlighted (r). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Journal: Journal of Advanced Research

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft

    doi: 10.1016/j.jare.2025.07.059

    Figure Lengend Snippet: The impact of DRG neuron axonal promotion via SKP-SCs. (a) Schematic illustration of DRG neurons culture in vitro. The cultured DRG neurons for 20 h and 40 h (b) showed increased neurite outgrowth. Scale bar: 50 μm. (c) The β-Tubulin III cell immunofluorescent staining (red) showed neurites are undergoing a process of growth in length from 48 h to 96 h. Scale bar: 50 μm. Schematic illustration showed the direct (d) and in-direct (Transwell®) (e) co-culture of DRG neurons and SKP-SCs. (h) After direct co-culture 48 h, GFP-SKP-SCs promoted DRGs neurite outgrowth significantly compared to control group (i). (k) After in-direct co-culture 72 h, GFP-SKP-SCs promoted DRGs neurite outgrowth (j) significantly compared to control group (g). Scale bar: 50 μm for f, g, i, j. (l) Morphological changes under phase contrast microscopy in DRG neurons and SKP-SCs direct co-culture, DRG neurons in separate culture, and in-direct (Transwell®) co-culture of DRG neurons and SKP-SCs after 24 h, 48 h, and 72 h. Scale bar: 100 μm. (m) Schematic illustration of LC-MS/MS analysis to identify the secreted proteins from SKP-SCs cultured in serum free basic medium for 4 h. After concentration, the cleared conditioned medium was collected for LC-MS/MS analysis, database search, and protein identification. The enrichment analysis showed top 20 diseases and functions (n) and canonical pathways (o) according to the IPA database. The PPI network shows the interaction of the proteins involved in the functions highly correlated with regeneration (p). Among them, functions as formation of lamellipodia, extension of neurites, extension of cellular protrusions, and related proteins were highlighted (q). Functions as migration of endothelial cells, development of endothelial tissue, vasculogenesis, development of epithelial tissue, endothelial cell development, and related proteins were highlighted (r). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Article Snippet: The Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA) was employed to identify canonical pathways that are significantly overrepresented.

    Techniques: In Vitro, Cell Culture, Staining, Co-Culture Assay, Control, Microscopy, Liquid Chromatography with Mass Spectroscopy, Concentration Assay, Migration, Activation Assay, Inhibition

    The transcriptional alteration of DRG neurons co-cultured with SKP-SCs. (a) Representative images of phase contrast microscopy of SKP-SCs in the upper chamber and lower ventricular DRG neurons after 48 h co-culture. Scale bar: 100 μm. (b) Schematic illustration of transcriptional analysis of lower ventricular DRG neurons for 48 h co-culture, and bioinformatics. The enrichment analysis showed top 20 diseases and functions (c) and canonical pathways (d) according to the IPA database. The PPI network shows the interaction of the key proteins involved in the functions highly correlated with regeneration (e). Up-regulated EGR2 (red) was selected to show multi-functions highly correlated with neuroregeneration (f). The interaction network of downstream regulators of EGR2, its downstream up-regulated (red) genes and down-regulated (green) proteins and their functions (g). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. Color intensity of the nodes in networks were proportional to differentially expression level. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Journal: Journal of Advanced Research

    Article Title: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft

    doi: 10.1016/j.jare.2025.07.059

    Figure Lengend Snippet: The transcriptional alteration of DRG neurons co-cultured with SKP-SCs. (a) Representative images of phase contrast microscopy of SKP-SCs in the upper chamber and lower ventricular DRG neurons after 48 h co-culture. Scale bar: 100 μm. (b) Schematic illustration of transcriptional analysis of lower ventricular DRG neurons for 48 h co-culture, and bioinformatics. The enrichment analysis showed top 20 diseases and functions (c) and canonical pathways (d) according to the IPA database. The PPI network shows the interaction of the key proteins involved in the functions highly correlated with regeneration (e). Up-regulated EGR2 (red) was selected to show multi-functions highly correlated with neuroregeneration (f). The interaction network of downstream regulators of EGR2, its downstream up-regulated (red) genes and down-regulated (green) proteins and their functions (g). Orange nodes stand for a predicted activation state. Blue nodes stand for a predicted inhibition state. Color intensity of the nodes in networks were proportional to differentially expression level. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

    Article Snippet: The Ingenuity Pathway Analysis (IPA) software suite (Ingenuity Systems, Redwood City, CA) was employed to identify canonical pathways that are significantly overrepresented.

    Techniques: Cell Culture, Microscopy, Co-Culture Assay, Activation Assay, Inhibition, Expressing